Is there a role for melatonin in the intensive care unit?
In the last decade, there have been significant developments in the understanding of the hormone melatonin in terms of its physiology, regulatory role and potential utility in various domains of clinical medicine. Melatonin’s purported properties include, among others, regulation of mitochondrial function, anti-inflammatory, anti-oxidative and neuro-protective effects, sleep promotion and immune enhancement. As such, its role has been explored specifically in the critical care setting in terms of many of these properties. This review addresses the physiological basis for considering melatonin in the critical care setting as well as the current evidence pertaining to its potential utility.
G Richards, Department of Critical Care, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
A Bentley, Department of Family Medicine, Faculty of Heath Sciences, University of the Witwatersrand, Johannesburg, South Africa
D Gopalan, Discipline of Anaesthesiology and Critical Care, School of Clinical Medicine, University of KwaZulu-Natal, Durban, South Africa
L Brannigan, Department of Critical Care, WITS Donald Gordon Medical Centre, University of the Witwatersrand, Johannesburg, South Africa
F Paruk, Department of Critical Care, Faculty of Health Sciences, Steve Biko Academic Hospital, University of Pretoria, South Africa
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Date published: 2021-08-06
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